RS 504393

CAS No. 300816-15-3

RS 504393( —— )

Catalog No. M20120 CAS No. 300816-15-3

RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 88 In Stock
10MG 151 In Stock
25MG 332 In Stock
50MG 498 In Stock
100MG 718 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    RS 504393
  • Note
    Research use only, not for human use.
  • Brief Description
    RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
  • Description
    RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    CCR
  • Recptor
    CCR2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    300816-15-3
  • Formula Weight
    417.51
  • Molecular Formula
    C25H27N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mg/mL (23.95 mM); Water: Insoluble
  • SMILES
    Cc1oc(nc1CCN1CCC2(CC1)OC(=O)Nc1ccc(C)cc21)-c1ccccc1
  • Chemical Name
    6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-31-benzoxazine-44'-piperidin]-2(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mirzadegan T et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.
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