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RS 504393

CAS No. 300816-15-3

RS 504393( —— )

Catalog No. M20120 CAS No. 300816-15-3

RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 151 In Stock
25MG 332 In Stock
50MG 498 In Stock
100MG 718 In Stock
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Biological Information

  • Product Name
    RS 504393
  • Note
    Research use only, not for human use.
  • Brief Description
    RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
  • Description
    RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    CCR
  • Recptor
    CCR2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    300816-15-3
  • Formula Weight
    417.51
  • Molecular Formula
    C25H27N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mg/mL (23.95 mM); Water: Insoluble
  • SMILES
    Cc1oc(nc1CCN1CCC2(CC1)OC(=O)Nc1ccc(C)cc21)-c1ccccc1
  • Chemical Name
    6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-31-benzoxazine-44'-piperidin]-2(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mirzadegan T et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.
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